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Results: Distribution of alleles (A and C) and genotypes (AA, CA and CC) AQP5 1364A/C in patients with sepsis or sepsis subgroups (sepsis with no septic shock and sepsis shock patients) versus control group (healthy volunteers) did not differ. Data were analyzed by Kaplan-Meyer plot and Fisher test, and odds ratios were calculated. AQP5 polymorphism was studied by analyzing PCR products in a 2% agarose gel using a AQP5 1364A/C specific tetra primer set. Study groups (n=152) included ICU patients with abdominal sepsis (AS, including pancreatitits, peritonitis, cholecystitis, appendicitis n=98) and sepsis patients with other sources of infections. Methods: Sepsis and septic shock were defined in patients according to SEPSIS-3 (2016) recommendations.
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To increase the informative value of the prediction and decrease the cost, it might be crucial to determine at a pre-test level the subset of patients who might benefit most from the prognostic genotyping. Studies by Adamzik and colleagues have demonstrated that aquaporin AQP5 polymorphism (1364A/C, rs3759129) associates with increased 30-day survival in sepsis patients presumably due to increased gene expression that enhance the leukocyte migration. Introduction: The purpose of the study was to determine whether the preferential localization of the infection and age affect the prognostic value of the genetic marker AQP5 (1364A/C, rs3759129) in outcome prediction in sepsis patients. P001 Prognostic value of a genetic polymorphism of AQP5 in sepsis depends on a source of infection V Pisarev 1, A Chumachenko 1, I Tyurin 2, R Cherpakov 2, A Tutelyan 3 1Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A.Negovsky Institute of General Reanimatology, Moscow, Russia 2V.M.Buiyanov City Clinical Hospital, Anesthesia-Reanimatology Department, Moscow, Russia 3Central Institute of Epidemiology, Moscow, Russia